Administration Considerations Amid the Large-Volume Subcutaneous Injection Revolution

In nursing school, we learned that the maximum volume for a single subcutaneous (SC) injection is 1.5–2 ml. However, today’s unique antineoplastic formulations may require volumes up to 15 ml (e.g., daratumumab and hyaluronidase-fihj), forcing nurses to rethink administration practices. Currently, evidence on large-volume SC administration procedures is sparse, making it difficult to determine best practice.