Flemming, K. (2010). The use of morphine to treat cancer-related pain: A synthesis of quantitative and qualitative research. Journal of Pain and Symptom Management, 39(1), 139–154.
Electronic searches retrieved a total of 2,886 records. After screening by title, 255 abstracts were retrieved for initial review. Of these the author obtained 30 articles for full review. Reference chaining yielded another 10 articles. A final sample of 19 resources met criteria and were analyzed. The author used a quality-appraisal checklist. Findings from each qualitative report were identified and compared with recommendations regarding effectiveness. Two resources provided the framework of comparison: Cochrane Systematic Review of Oral Morphine for Cancer Pain and the European Association for Palliative Care recommendations regarding use of opioids for cancer pain.
The study resulted in the synthesis of four arguments.
Patients were selective about their disclosure of pain severity. The degree of confidence and trust in providers influenced reporting about pain, treatment choices, and use of opioids. Negative feeling toward providers led to reluctance to report pain.
This review provides a wealth of powerful and meaningful information that healthcare professionals can use to improve how they work with patients and caregivers in the management of cancer-related pain. Findings suggest that many professionals still have concerns about addiction with the use of opioids in the treatment of chronic cancer pain and that these professionals intentionally or unintentionally communicate these concerns, adversely influencing patients' and caregivers' experiences. Findings point to the importance of aggressive management and prevention of adverse side effects from opioids, to have a positive effect on the patient’s sense of the trade-offs involved with opioids. Findings support the concept that a team approach involving providers, caregivers, and patients and trust among team members are crucial to effective pain management.
Nurses can use the themes to guide open discussion and to anticipate potential issues regarding the use of opioids for pain management.
Fleming, S., Yannakou, C.K., Haeusler, G.M., Clark, J., Grigg, A., Heath, C.H., . . . Slavin, M.A. (2014). Consensus guidelines for antifungal prophylaxis in haematological malignancy and haemopoietic stem cell transplantation, 2014. Internal Medicine Journal, 44, 1283–1297.
RESOURCE TYPE: Consensus-based guideline
PROCESS OF DEVELOPMENT: Not fully described. Provides only search terms used
Not stated
No quality grading of evidence
Provides information regarding risk factors for consideration in determining the specific type of prophylactic agent to be used, and provides comprehensive information regarding metabolism, etc., of individual antifungals.
Fleming, L., Randell, K., Harvey, C.J., & Espie, C.A. (2014). Does cognitive behaviour therapy for insomnia reduce clinical levels of fatigue, anxiety and depression in cancer patients? Psycho-Oncology.
To explore relationships among variables and evaluate change in symptoms following cognitive behavioral therapy for insomnia (CBTI)
This paper reports a secondary analysis of a randomized controlled trial of CBTI delivered in group sessions over five weeks. Assessments done at baseline and post-treatment were analyzed.
PHASE OF CARE: Transition phase after active treatment
Secondary analysis of a randomized controlled trial
The most common symptom cluster reported was insomnia, anxiety, and fatigue (18% of patients). Clinical-level insomnia was reduced by 52% in the CBTI group compared to a 17.5% reduction in the usual care controls post-intervention (p < .001). CBTI resulted in a 10.9% reduction in rate of clinical levels of fatigue, compared with a 2.5% increase in control patients post-treatment (p = .03). Anxiety rates did not change. Most patients were not clinically depressed at baseline, and no significant differences were seen between groups in depression rates post-intervention.
The CBTI reduced prevalence of insomnia and clinically relevant fatigue.
Findings support the use of CBTI for sleep/wake disturbance and fatigue management in patients after cancer treatment. Follow-up in this report was immediately after five weeks of the intervention only, so how long-lasting any effects are is not clear.
Flank, J., & Dupuis, L.L. (2014). Comparative effectiveness research in antineoplastic-induced nausea and vomiting control in children. Journal of Comparative Effectiveness Research, 3, 185–196.
PHASE OF CARE: Active antitumor treatment
APPLICATIONS: Pediatrics
Two studies addressed the comparative pediatric evidence related to the selection of a 5HT3 receptor antagonist. One study found a complete control rate of nausea and vomiting of 30% with tropisetron (8 out of 27) and 32% with granisetron (7 out of 22). The other study found a complete control rate of 61% with granisetron (20 out of 33) and 45.5% (15 out of 33) with ondansetron. Three other studies showed improved control of AINV when a corticosteroid was used with a 5HT3 receptor antagonist versus an antiemetic alone in patients receiving highly emetogenic chemotherapy (HEC). Another comparison between the use of IV versus oral 5HT3 receptor antagonists found equivalent effectiveness when used for HEC or moderately emetogenic chemotherapy (MEC).
Because of inconsistencies in the the research studies' methodologies related to pediatric AINC, there were few comparative effectiveness research (CER) examples. The evidence available to support guidelines is of low quality, and many research gaps exist. Barriers related to CER in pediatric AINV include patient factors, discrepancies related to research design, and definitions of complete control, outcomes, and outcome measures.
Insufficient evidence to develop comprehensive guidelines or for CER for AINV control in pediatric patients
Research related to pediatric AINV control is very limited and lacks in quality for comparison. The conclusions ascertained from this article were that children who used a corticosteroid with a 5HT3 receptor antagonist experienced increased efficacy of AINV control, and both IV and oral routes of these drugs have similar efficacy when used with HEC and MEC.
Flank, J., Thackray, J., Nielson, D., August, A., Schechter, T., Alexander, S., . . . Dupuis, L.L. (2015). Olanzapine for treatment and prevention of acute chemotherapy-induced vomiting in children: A retrospective, multi-center review. Pediatric Blood and Cancer, 62, 496–501.
To explore the efficacy and safety of olanzapine in children aged 3–17 years for chemotherapy-induced vomiting (CIV) control
This was a retrospective review of 60 children (158 chemotherapy blocks) who received olanzapine for acute CIV control at institutions in Canada and the United States over a 30-month period. All CIV data were abstracted from the childrens' health records.
Retrospective chart audit
Sixty children were given olanzapine in 128 blocks of chemotherapy on the first day of chemotherapy (usually highly emetogenic chemotherapy). Children in 125 of the 128 blocks received ondansetron or granisetron, dexamethasone (55%), or aprepitant (18%). Acute-phase CIV control was obtained in 83 (65%) blocks. There was no association between complete response and the olanzapine dose. The most commonly reported side effects were sedation (7%) and increased plasma transaminase concentrations (5%).
Olanzapine may be a useful option for CIV control in pediatric patients. However, the findings from this study were inconclusive regarding clinical efficacy.
Nurses caring for children with acute CIV should know that olanzapine in a well-monitored situation may be a safe alternative. However, its efficacy was unclear in this study. A prospective study to determine the role of olanzapine alone and in combination with other antiemetics for varied levels of emetogenicity is warranted.
Flank, J., Robinson, P.D., Holdsworth, M., Phillips, R., Portwine, C., Gibson, P., . . . Dupuis, L.L. (2016). Guideline for the treatment of breakthrough and the prevention of refractory chemotherapy-induced nausea and vomiting in children with cancer. Pediatric Blood and Cancer, 63, 1144–1151.
RESOURCE TYPE: Evidence-based guideline
Five thousand nine hundred ninety-three citations were retrieved, and 59 studies were included—13 for breakthrough CINV and 46 for refractory CINV. Very limited evidence in children existed, of which much was weak, as well as evidence regarding the safety and optimal dosages of breakthrough medications, such as metoclopramide and methotrimeprazine, for children.
The review and guideline development process were conducted very well, but limitations include the lack of sufficient evidence for interventions in pediatric patients. Even those recommendations that were presented as strong recommendations were noted to be based on weak evidence.
This guideline provides specific recommendations for alterations in CINV prophylaxis to address breakthrough and refractory CINV in children. It has also exposed research gaps in the areas of efficacy of prophylaxis escalation, optimal dose, efficacy and safety of olanzapine, methotrimeprazine and metoclopramide, optimal palonosetron dose with multiple day chemotherapy, and the extent and clinical significance of interactions between aprepitant and chemotherapy. Safety of metoclopramide in children related to side effects of extrapyramidal symptoms is also questioned.
FitzHenry, F., Wells, N., Slater, V., Dietrich, M.S., Wisawatapnimit, P., & Chakravarthy, A.B. (2013). A randomized placebo-controlled pilot study of the impact of healing touch on fatigue in breast cancer patients undergoing radiation therapy. Integrative Cancer Therapies, 13, 105-113.
To compare weekly healing touch to weekly sham therapy on fatigue in women receiving radiation therapy for breast cancer
Participants were randomized to receive either weekly healing touch or weekly sham therapy. Participants were blinded to group assignment. Each session was 45 minutes in length. Participants either wore a neck drape or blindfold so as not to see how the treatment was delivered.
Depression was positively correlated with fatigue measures. Anxiety was positively associated with fatigue interference. Healing touch participants reported higher levels of fatigue throughout study than control participants. The control group reported greater reduction in fatigue than did the healing touch group.
This pilot study demonstrated that the intervention was feasible. However the study did not demonstrate any benefit in reduction of fatigue in this small sample.
Healing touch is not harmful to patients, but this small study does not support its use to reduce fatigue in women receiving radiation therapy for breast cancer.
Fisher, J., Scott, C., Stevens, R., Marconi, B., Champion, L., Freedman, G. M., … Wong, G. (2000). Randomized phase III study comparing best supportive care to Biafine as a prophylactic agent for radiation-induced skin toxicity for women undergoing breast irradiation: Radiation Therapy Oncology Group (RTOG) 97–13. International Journal of Radiation Oncology, Biology, Physics, 48, 1307–1310.
To determine if Biafine was more effective than best supportive care (BSC) in preventing or reducing radiation (RT)-induced dermatitis.
Randomizaton to Biafine versus BSC depended on the institution and included aloe, Aquaphor, other interventions, and no treatment.
Patients were stratified by bra size: small (32ab, 34ab, 36a), medium (32c, 34c, 36bc, 38abc), or large (all others).
The study was a randomized, controlled trial.
Fisher, M.I., Donahoe-Fillmore, B., Leach, L., O'Malley, C., Paeplow, C., Prescott, T., & Merriman, H. (2014). Effects of yoga on arm volume among women with breast cancer related lymphedema: A pilot study. Journal of Bodywork and Movement Therapies, 18, 559-565.
PURPOSE: To study the effects of yoga on limb volume in women with breast cancer-related lymphedema
SECONDARY OBJECTIVES: To determine the effects of eight weeks of yoga on quality of life, self-reported arm function, and grip strength
Participants attended eight weeks of Hatha yoga three times a week. Participants went to the studio two times per week (60 minutes) and watched a prerecorded DVD at home (45 minutes) once per week. They all wore compression sleeves.
Pilot study with a pre- and postintervention design
It was too early to conclude that yoga benefits breast cancer-related lymphedema. Many variables may affect arm reduction such as body mass index and duration of disease. Participants had lymphedema for greater than seven years, and their lymphedema may have been less influenced by activity and therapy. It is likely that the length of the intervention is was long enough to affect quality of life.
Many evidenced-based guidelines encouraging exercise, including yoga, exist for the breast cancer patient population. However, there is a lack of data available regarding the effects of yoga on lymphedema. Nurses can confidently refer patients to an instructor-based program or a physical therapist for safe upper body exercise. More studies with rigorous designs are needed to examine the impact of yoga on patients with cancer-related lymphedema.
Fisher, B.T., Kavcic, M., Li, Y., Seif, A.E., Bagatell, R., Huang, Y.S., . . . Aplenc, R. (2014). Antifungal prophylaxis associated with decreased induction mortality rates and resources utilized in children with new-onset acute myeloid leukemia. Clinical Infectious Diseases, 58, 502–508.
To evaluate the effectiveness of antifungal prophylaxis in children with acute myeloid leukemia (AML)
Medical data for children newly diagnosed with AML were obtained from a database of hospitals associated with the Children's Hospital Association nationwide. Only patients with AML receiving induction therapy involving cytarabine, aunorubicin, and etoposide regimens were included. Patients were followed until inpatient death, loss to follow-up, or completion of induction. Data for antibiotic use, blood cultures, and chest CTs were obtained. Exposure to antifungal prophylaxis with any agent was obtained, and decision rules were used to ensure antifungals were used for prophylaxis rather than empiric therapy. Those who did not receive any antifungal agent during the first 21 days of induction chemotherapy were considered “no prophylaxis” patients. Outcomes were analyzed and compared for those who did and did not receive prophylaxis
Of those who did not get antifungal prophylaxis, 5.32% died during induction compared to 2.42% of those receiving prophylaxis (RR = 0.42, 95% CI [0.19, 0.9]). Those receiving prophylaxis had less use of antibiotics and fewer blood cultures and CT scans. There was no significant difference in mortality between those receiving anti-mold prophylaxis and others.
Findings show that primary antifungal prophylaxis was associated with lower mortality and utilization of resources during induction for AML among pediatric patients.
Findings suggest that primary antifungal prophylaxis among pediatric patients may reduce mortality and resource utilization. These findings support the use of antifungal prophylaxis among at-risk pediatric patients.