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Proton pump inhibitors reduce the amount of gastric acid secreted in the stomach, resulting in the stabilization of blood clots (Kim et al., 2017; Neumann et al., 2013). Proton pump inhibitors have been used in the treatment of bleeding ulcers and are recommended by current guidelines for management of nonvariceal upper gastrointestinal (GI) bleed and for the prevention of recurrent bleeding in certain patients (Gralnek et al., 2015; Hwang et al., 2012; Kim et al., 2017).