CML Physical Presentation

The typical physical presentation of CML is that of splenomegaly, which may present as minimal to profound. It is often first diagnosed through a routine examination, as patients may not complain of any presenting symptoms. In about 10% of patients, splenomegaly is absent at presentation (National Cancer Institute, 2011b). When the symptoms do occur, they tend to develop gradually and are consistent with many other diseases. Symptoms include

  • Lethargy
  • Shortness of breath upon exertion
  • Pale skin
  • Discomfort in warm temperatures
  • Fever
  • Unexplained weight loss
  • Feeling full after eating a small amount of food
  • Night sweats.
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